Leptin, the brain and Type 2
Downstream mechanisms underlying leptin modulation of POMC neuronal excitability and energy homeostasis.
- Dr Mark Smith of Imperial College London
- £211,726; Three-year project grant
- October 2012 – October 2015
Background to project
Leptin is a hormone that has a key role in the control of appetite and metabolism. It also helps to regulate the electrical activity of cells in the brain that control energy balance, although the precise mechanisms involved are unclear.
Type 2 diabetes is particularly common in obese individuals who may be resistant to insulin and leptin. Studies suggest that blocking the action of these hormones leads to obesity but that insulin and leptin have distinct impacts on physiology.
Project aims
This project at Imperial College London will investigate the signalling mechanisms in the brain by which leptin influences energy balance and body weight, in order to distinguish the roles of leptin and insulin.
Dr Mark Smith and his team will use experiments in mice to see if blocking particular signalling molecules will prevent leptin from modifying electrical activity in the brain and from regulating metabolism. They will also determine whether blocks in signalling will limit the progression of obesity and Type 2 diabetes.
Potential benefit to people with diabetes
This research will help to identify signalling molecules that are influenced by leptin and insulin. Although it is currently at an early stage, it is key to the long-term goal of producing drugs that will help to reduce body weight and prevent the development of Type 2 diabetes.