Understanding the role of GLP-1
New RD Lawrence Fellowship
Regulation of glucagon secretion by GLP-1: a role for GLP (9-36) mediated by a novel GLP-1 receptor?
- Dr Reshma Ramracheya of the University of Oxford
- £499,404; five-year RD Lawrence Fellowship
- May 2012 – May 2017
Background to project
Type 1 and Type 2 diabetes are marked by insufficient release of insulin and over-production of glucagon, a hormone that elevates blood glucose by causing it to be released from stores in the liver. Glucagon-like peptide-1 (GLP-1) is a protein that is being investigated as a potential treatment for diabetes because it increases insulin production and reduces the production of glucagon.
Project aims
The exact mechanisms by which GLP-1 takes effect are poorly understood, but Dr Ramracheya believes that an undiscovered receptor may be involved. Using human and mouse islets in the laboratory, she will attempt to clarify these mechanisms and identify the new receptor that might be involved.
Potential benefit to people with diabetes
Findings from this Fellowship could lead to new therapies for accurately targeting the overproduction of glucagon in both Type 1 and Type 2 diabetes.