Care and treatment
Early detection
If you would like to view all of the ongoing projects that we are funding, please download the project directory.
Care and treatment: early detection and improved treatment
Professor Graham Foster, Dr William Drake, Dr John Monson & Dr Norman Taylor
St Bartholomew’s Hospital, London
£10,000; one year Small Grant
An investigation of corticosteroid metabolism in hyperinsulinaemic diabetic patients with and without non-alcoholic steatohepatitis
Patients with diabetes and those exposed to too much steroid often have deposition of fat within their liver. It is known that different people generate and dispose of steroid hormones at different rates. This study will look at how important the different rates of generation are.
Fully subscribed – no longer available for adoption
Dr Pamela Greenwell, Ms Bibi Jauhangeer, Mr Michael Wren & Dr Jonathan Pratten
University of Westminster, London
£10,000; one year Small Grant
The role of anaerobic bacteria, small peptide molecules and biofilms in diabetic foot ulcers
This study will look at the interaction between different bacteria that grow in the presence and absence of oxygen in diabetic foot ulcers.
Adopted by: Northampton Voluntary Group
Fully subscribed – no longer available for adoption
Dr Geraint Jones, Mr Neil Baker, Dr Michael
Edmonds, Dr William Jeffcoate & Dr Edward Jude
Blackburn Royal Infirmary
£33,116; two year Project Grant
The establishment of a collaborative network for the study of the Charcot foot
The aim of this project is to improve knowledge of the Charcot foot by establishing a collaborative network of clinicians throughout the UK. This will be used to pool clinical experience and facilitate future research.
Adopted by: Blackburn & District Voluntary Group; Burnley, Pendle & Rossendale Group.
Fully subscribed – no longer available for adoption
Dr Edward Jude, Dr Simon Page, Dr Michael Edmonds & Professor Andrew
BoultonTameside General Hospital, Lancashire
£205,623; three year Project Grant
Oral bisphosphonate, Alendronate, in the treatment of diabetic Charcot neuropathy
A trial recently showed some beneficial effects of an intravenous bisphosphonate (drugs that inhibit the re-absorption of bone and are use to strengthen bone) but did not show a difference in disease activity. This study will be larger and use newer and more potent oral bisphosphonate, whilst comparing it to a placebo.
Dr Brenda Leckie
Leicester Royal Infirmary
£7582; one year Small Grant
Identification of a human prorenin receptor involved in diabetic microvascular disease
This work will identify a specific prorenin receptor (enzyme precursor) which may be present on endothelial cells and contribute towards the development of microvascular disease and neuropathy.
Fully subscribed – no longer available for adoption
Dr Phil Stephens, Professor David Thomas, Professor Keith Harding & Professor Patricia Price
University of Wales College of Medicine, Cardiff
£143,010; three year Project Grant
Investigating the role of cellular senescence and extracellular matrix remodelling in impaired wound healing in diabetic patients
This project will study for the first time the relationship between diseased and normal skin cells in people with diabetes – this may aid our knowledge of wound healing, particularly in relation to diabetic foot ulcers.
Adopted by: Wimbledon & District Voluntary Group