Complications
Nephropathy
If you would like to view all of the ongoing projects that we are funding, please download the project directory.
Complications: nephropathy
Dr Alan Bevington & Dr Terry Herbert
University of Leicester
£40,500; three year Joint Diabetes UK/Kidney Research UK Studentship
The role of the hexosamine pathway in global protein synthesis and protein wasting states
This project proposes that acid accumulation in kidney patients blocks the ability of insulin to maintain production of the protein molecules from which muscle cells are built.
Adopted by: Solihull Voluntary Group; Gainsborough & District Voluntary Group
Dr Prabal Chaterjee
University of Brighton
£69,100; three year Joint Diabetes UK/Kidney Research UK Studentship
Glucotoxicity and diabetes neuropathy: Investigating the role of superoxide dismutase and endoplasmic reticulum stress
The project aims to increase our understanding of the cellular mechanisms involved in diabetic nephropathy in the hope that it will lead to the development of new therapies.
Dr Luigi Gnudi, Professor Rudy Bilous & Dr Giancarlo Viberti
King’s College London
£164,724; three year Project Grant
GLUT-1 inducible over expression in podocytes: potential trigger for the development of diabetic glomerulopathy
This research hypothesises that in diabetic glomerulopathy, podocytes (which are crucial in regulating filtration of blood and formation of urine) are central in triggering events that subsequently lead to diabetic renal impairment.
Adopted by: Luton Voluntary Group; Bishop Auckland Group
Dr Luigi Gnudi, Dr Richard Siow, Dr Giancarlo Viberti & Dr Giovanni Mann
King’s College London, London
£146,111 three year Project Grant
Impaired antioxidant response to metabolic and haemodynamic perturbations in human mesangial cells: implications for extracellular matrix production in diabetic glomerulopathy
This project proposes to study the mechanisms underlying the protection afforded by antioxidant proteins within kidney cells and to further characterise the molecular mechanisms involved in diabetic microvascular complications in the kidney.
Adopted by: Luton Voluntary Group
Professor Peter Maxwell
Queen’s University, Belfast
£40,500; three year Joint Diabetes UK/Kidney Research UK Studentship
Identification of genetic risk factors for diabetic nephropathy
Diabetic nephropathy has emerged as the commonest cause of end stage renal disease. Family clustering has shown a genetic susceptibility to diabetic kidney disease. This research will use various methods to study this genetic susceptibility.
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