Our research projects

We fund world class research

At any one time, we have around 120 research projects making discoveries across the UK. Each of these projects is only possible thanks to the generous support of our members, donors and local groups

Every project is reviewed by experts and approved by our research committee and our panel of people living with diabetes. So you're supporting research of the highest scientific quality, led by researchers with the skills and experience to succeed.

Your support of our research projects means we can keep tackling the complications of diabetes and bring us one step closer to a cure.

Find a research project

Use the search tool to discover research taking place in your local area, or choose a subject or type of diabetes you’re interested in.

Each project page showcases the details of the research, and if you find a research project you could really get behind, you can support it in lots of different ways.

122 results found

Filters
Research Area
Region
Subject

Protecting the blood vessels in diabetes

Project:
South West - Bristol
Status:
Project available for adoption
Tags:
Type 1 and Type 2
England - South West
South West
Complications
Project Summary

Blood vessels are lined with endothelial cells, which have a protective coating. This coating can become damaged in diabetes, leading to the development of complications like stroke, heart attack and kidney disease. Dr Satchell will study the coating in more detail to see if it can be used as a treatment to protect blood vessels in people with diabetes.

Stopping thymic B cells in Type 1 diabetes

Project:
Northern & Yorkshire - York
Status:
Project available for adoption
Tags:
Type 1
Causes
England - Northern & Yorkshire
Northern & Yorkshire
Project Summary

The thymus helps to destroy ‘bad’ immune cells that attack the body, but this doesn’t happen in people with Type 1 diabetes. Dr Allison Green will find out why and how the thymus stops working properly in people with Type 1 diabetes, which could lead to treatments to prevent the condition.

Are Type 2 drugs safe and effective for Type 1?

Project:
Leicester - Midlands
Status:
Project not available for adoption
Tags:
England - Midlands
Type 1
Healthcare
Project Summary

Drugs commonly used to treat Type 2 diabetes - called gliflozins - may also be beneficial for people with Type 1 diabetes. Professor Melanie Davies will find out if these drugs are safe to use, and can help to control blood glucose levels, in people with Type 1. This could offer a new way to help people with Type 1 diabetes improve their blood glucose control. 

Helping the immune system tackle Type 1 diabetes

Project:
London
Status:
Project available for adoption
Tags:
Type 1
England - London
London
Towards a cure
Prevention
Project Summary

Immune cells called Tregs police the immune system and stop it from attacking healthy cells. But in Type 1 diabetes, this goes wrong. Professor Federica Marelli-Berg has found a drug that helps Tregs work better. She’ll test this drug to see if it can prevent or slow the progression of Type 1 diabetes. In the future, this could lead to life-changing new treatments for people with or at risk of the condition.

Banking on retinopathy research

Project:
London
Status:
Project available for adoption
Tags:
England - London
Complications
Type 1 and Type 2
London
Project Summary

Professor Marcus Fruttiger and his team will collect and study eyes donated by people with diabetic retinopathy after their death. This will help to improve our understanding of what leads to retinopathy and lay the foundation for a retinopathy tissue bank that will, in the long run, become a valuable resource for research in this area.

The inner workings of blood vessels

Project:
England – London
Status:
Project available for adoption
Tags:
Complications
Innovation
England
London
Type 1
Type 1 and Type 2
Type 2
Project Summary

Cells that line the inside of blood vessels can become damaged in people with diabetes. Dr Aranzazu Chamorro Jorganes is zooming in on the careful balance of molecules inside those cells, to find out how diabetes throws the balance off. Understanding more about blood vessel damage on a molecular level could uncover new ways to restore blood vessels back to full health in people with diabetes.

Unlocking new treatments for diabetic eye disease

Project:
London
Status:
Project available for adoption
Tags:
Complications
Type 1 and Type 2
England - London
London
Project Summary

Professor Stephen Moss has found a protein involved in retinopathy. He now wants to understand precisely how it causes damage to blood vessels in the eye and test whether blocking its activity could help to prevent retinopathy in mice. This research could help us to understand how people with diabetes develop eye damage and find new, better treatments to stop it.

Breaking down blood clots to tackle complications

Project:
Leeds
Status:
Project available for adoption
Tags:
Type 1 and Type 2
Complications
Northern & Yorkshire
England - Northern & Yorkshire
Project Summary

Blood clots are a key cause of heart attacks and strokes and are often more difficult to break down in people with diabetes. Dr Ramzi Ajjan will use state-of-the-art techniques to identify small proteins that could help to break clots down, and then test out their effects. This research could lead to new treatments that protect people with diabetes from life-threatening complications.

Keeping kidney cells talking

Project:
Midlands - Lincoln
Status:
Project available for adoption
Tags:
Complications
Type 1 and Type 2
Midlands
Project Summary

Dr Hills wants to understand why kidney cells can’t function properly in people with diabetes. She’ll be looking at how high glucose levels, combined with a specific stress molecule, change the behaviour of kidney cells. This study could help to identify new drugs to prevent or treat kidney disease in the future.

Why is exercise good for people with Type 2 diabetes?

Project:
Birmingham, Midlands
Status:
Project available for adoption
Tags:
Healthcare
Type 2
Midlands
England
Innovation
Project Summary

We know that exercise is good for people with Type 2 diabetes, but Dr Barlow would like to understand the relationship between the two better. He’ll look at the direct effects of muscle contraction on insulin-producing beta cells in the pancreas, to find out exactly why exercise is beneficial for people with Type 2 diabetes and how this could be maximised in the future.

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