Our research projects

We fund world class research

At any one time, we have around 120 research projects making discoveries across the UK. Each of these projects is only possible thanks to the generous support of our members, donors and local groups

Every project is reviewed by experts and approved by our research committee and our panel of people living with diabetes. So you're supporting research of the highest scientific quality, led by researchers with the skills and experience to succeed.

Your support of our research projects means we can keep tackling the complications of diabetes and bring us one step closer to a cure.

Find a research project

Use the search tool to discover research taking place in your local area, or choose a subject or type of diabetes you’re interested in.

Each project page showcases the details of the research, and if you find a research project you could really get behind, you can support it in lots of different ways.

22 results found

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Subject

Lymphatics: a new treatment target for kidney disease in people with diabetes?

Project:
London
Status:
Project available for adoption
Tags:
Complications
London
England
Type 1 and Type 2
Project Summary

Dr David Long and his colleagues are investigating the function of kidney lymphatic vessels in diabetic kidney disease. This will help us to understand whether targeting lymphatic vessels could be a novel treatment strategy for diabetic kidney disease. 

Targeted treatment for Type 2 risk

Project:
London
Status:
Project has less than a year to run
Tags:
Type 2
London
England
Prevention
Project Summary

Dr Nicola Guess will investigate the benefits of targeted treatment for different groups of people at high risk of Type 2 diabetes.

She will use the dietary carbohydrate ‘inulin’ to try and improve glucose and insulin levels in people unlikely to benefit from changes to diet and physical activity levels.

Follicular helper T cells: are they an indication of Type 1 diabetes?

Project:
London
Status:
Project not available for adoption
Tags:
Type 1
London
England
Prevention
Towards a cure
Partnership
Project Summary

Professor Lucy Walker and her colleagues have found that a specific type of immune cell – called the follicular helper T cell – can trigger Type 1 diabetes in mice, and is more common in people with Type 1 diabetes.

The team now aims to understand exactly how follicular helper T cells cause Type 1 diabetes, and they will test new strategies to stop this from happening. They will test whether follicular helper T cells can be used as an early indication of the autoimmune response in Type 1 diabetes.

Can self-management therapies help with chronic pain?

Project:
London
Status:
Project available for adoption
Tags:
Complications
England
London
Type 1 and Type 2
Project Summary

Current treatment options for chronic pain in diabetes (also called painful diabetic neuropathy) are not very effective. A PhD student in Professor McCracken’s lab will investigate whether self-management strategies that focus around psychology could be used to manage pain better.

If successful, it will form a base for developing psychological therapies for people with painful diabetic neuropathy.

Helping the immune system tackle Type 1 diabetes

Project:
London
Status:
Project available for adoption
Tags:
Type 1
England - London
London
Towards a cure
Prevention
Project Summary

Immune cells called Tregs police the immune system and stop it from attacking healthy cells. But in Type 1 diabetes, this goes wrong. Professor Federica Marelli-Berg has found a drug that helps Tregs work better. She’ll test this drug to see if it can prevent or slow the progression of Type 1 diabetes. In the future, this could lead to life-changing new treatments for people with or at risk of the condition.

Banking on retinopathy research

Project:
London
Status:
Project available for adoption
Tags:
England - London
Complications
Type 1 and Type 2
London
Project Summary

Professor Marcus Fruttiger and his team will collect and study eyes donated by people with diabetic retinopathy after their death. This will help to improve our understanding of what leads to retinopathy and lay the foundation for a retinopathy tissue bank that will, in the long run, become a valuable resource for research in this area.

The inner workings of blood vessels

Project:
England – London
Status:
Project available for adoption
Tags:
Complications
Innovation
England
London
Type 1
Type 1 and Type 2
Type 2
Project Summary

Cells that line the inside of blood vessels can become damaged in people with diabetes. Dr Aranzazu Chamorro Jorganes is zooming in on the careful balance of molecules inside those cells, to find out how diabetes throws the balance off. Understanding more about blood vessel damage on a molecular level could uncover new ways to restore blood vessels back to full health in people with diabetes.

Unlocking new treatments for diabetic eye disease

Project:
London
Status:
Project available for adoption
Tags:
Complications
Type 1 and Type 2
England - London
London
Project Summary

Professor Stephen Moss has found a protein involved in retinopathy. He now wants to understand precisely how it causes damage to blood vessels in the eye and test whether blocking its activity could help to prevent retinopathy in mice. This research could help us to understand how people with diabetes develop eye damage and find new, better treatments to stop it.

Can chilli treat chronic foot pain?

Project:
London
Status:
Project available for adoption
Tags:
London
Type 1 and Type 2
Complications
Project Summary

Chronic pain in the feet, caused by nerve damage, is a debilitating complication of Type 1 or Type 2 diabetes. Professor Anand will test if a new treatment (called the capsaicin 8 percent patch) can reduce pain and potentially reverse nerve damage. If successful, this treatment could help to reduce the effects of chronic pain and improve quality of life in people with diabetes.

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