Our research projects

We fund world class research

At any one time, we have around 120 research projects making discoveries across the UK. Each of these projects is only possible thanks to the generous support of our members, donors and local groups

Every project is reviewed by experts and approved by our research committee and our panel of people living with diabetes. So you're supporting research of the highest scientific quality, led by researchers with the skills and experience to succeed.

Your support of our research projects means we can keep tackling the complications of diabetes and bring us one step closer to a cure.

Find a research project

Use the search tool to discover research taking place in your local area, or choose a subject or type of diabetes you’re interested in.

Each project page showcases the details of the research, and if you find a research project you could really get behind, you can support it in lots of different ways.

14 results found

Filters
Research Area
Region
Subject

Why does insulin resistance occur in Type 2 diabetes?

Project:
Northern & Yorkshire - Leeds
Status:
Project available for adoption
Tags:
England
Northern & Yorkshire
Type 2
Causes
Project Summary

Insulin resistance is a key feature of Type 2 diabetes. It affects the ability of the body’s cells to take in glucose and causes high blood glucose levels.

Professor Bryant will explore whether proteins involved in this process don’t work properly in people with Type 2 diabetes. This research could improve our understanding of what causes Type 2 diabetes and how to treat it.

Sleep disturbances and Type 2 diabetes

Project:
Northern & Yorkshire - Manchester
Status:
Project not available for adoption
Tags:
Type 2
England - Northern & Yorkshire
Northern & Yorkshire
Causes
Project Summary

Dr Martin Rutter plans to work out if sleep problems can help to predict who’s at risk of Type 2 diabetes. He’ll also look at whether sleep patterns in people with Type 2 diabetes can affect their blood glucose control and risk of complications. This research could help to prevent some people developing Type 2 diabetes and improve the health of people living with the condition.

The impact of islet transplantation

Project:
England - Newcastle
Status:
Project not available for adoption
Tags:
Type 1
England - Northern & Yorkshire
Northern & Yorkshire
Towards a cure
Project Summary

Professor James Shaw and his team will examine the effectiveness of islet transplants at different UK transplant centres, and the impact they can have on the wellbeing people living with Type 1 diabetes who have hypo unawareness. The team hope to gain a better understanding of which methods lead to the most successful transplants, and who could benefit the greatest in the long-term.

Targeting our body’s recycling system to treat Type 2 diabetes

Project:
Northern and Yorkshire
Status:
Project available for adoption
Tags:
Healthcare
Type 2
Northern & Yorkshire
Project Summary

Type 2 diabetes can get progressively worse over time, as insulin-producing cells in the pancreas stop working properly. Dr Catherine Arden believes something goes wrong with a ‘recycling’ process in our insulin-producing cells, known as autophagy. Her PhD students will carry out experiments to unravel how and why this happens. This could hold the key to finding new treatments to stop Type 2 diabetes from progressing in the future.

Not all fat’s the same: protecting against Type 2 diabetes

Project:
Northern & Yorkshire - Leeds
Status:
Project available for adoption
Tags:
Northern & Yorkshire
England
Type 2
Causes
Project Summary

Dr Roberts is focusing on fat cells, with different types responsible for storing and burning fat. He hopes to find specific signals from ‘good’ beige fat cells, to see if they can improve fat metabolism and protect the body from Type 2 diabetes.

If successful, this research could inform the development of new protective Type 2 diabetes treatments.

Stopping thymic B cells in Type 1 diabetes

Project:
Northern & Yorkshire - York
Status:
Project available for adoption
Tags:
Type 1
Causes
England - Northern & Yorkshire
Northern & Yorkshire
Project Summary

The thymus helps to destroy ‘bad’ immune cells that attack the body, but this doesn’t happen in people with Type 1 diabetes. Dr Allison Green will find out why and how the thymus stops working properly in people with Type 1 diabetes, which could lead to treatments to prevent the condition.

Breaking down blood clots to tackle complications

Project:
Leeds
Status:
Project available for adoption
Tags:
Type 1 and Type 2
Complications
Northern & Yorkshire
England - Northern & Yorkshire
Project Summary

Blood clots are a key cause of heart attacks and strokes and are often more difficult to break down in people with diabetes. Dr Ramzi Ajjan will use state-of-the-art techniques to identify small proteins that could help to break clots down, and then test out their effects. This research could lead to new treatments that protect people with diabetes from life-threatening complications.

How does the heart’s energy change in Type 2 diabetes?

Project:
Northern and Yorkshire
Status:
Project available for adoption
Tags:
Healthcare
Northern & Yorkshire
Type 2
Project Summary

Having Type 2 diabetes changes the way the heart generates the energy it needs to pump blood. Professor Sven Plein wants to know more about these changes, specifically in people who have narrow arteries – a common complication of Type 2 diabetes. Understanding the interaction between Type 2 diabetes and narrow arteries will help with the discovery of new, tailored treatments for people with Type 2 diabetes in the future.

The DiRECT route to Type 2 remission?

Project:
Scotland (Glasgow), and Northern and Yorkshire (Newcastle)
Status:
Project not available for adoption
Tags:
Scotland
Type 2
Northern & Yorkshire
England
Remission
Project Summary

With support from our largest ever research grant, Professors Mike Lean and Roy Taylor will investigate if a low-calorie diet, alongside weight management support, can put Type 2 diabetes into remission for the long-term. 

Their vital work will find out if a low-calorie, diet-based treatment should be offered as a routine treatment for Type 2 diabetes. In the future, this could help to reduce the number of people living with Type 2 diabetes.

Get all the latest news on how the low-calorie diet research is going so far.

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