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Our research projects

We fund world class research

At any one time, we have around 120 research projects making discoveries across the UK. Each of these projects is only possible thanks to the generous support of our members, donors and local groups

Every project is reviewed by experts and approved by our research committee and our panel of people living with diabetes. So you're supporting research of the highest scientific quality, led by researchers with the skills and experience to succeed.

Your support of our research projects means we can keep tackling the complications of diabetes and bring us one step closer to a cure.
 

Find a research project

Use the search tool to discover research taking place in your local area, or choose a subject or type of diabetes you’re interested in.

Each project page showcases the details of the research, and if you find a research project you could really get behind, you can support it in lots of different ways.

41 results found

Targeted treatment for Type 2 risk

Project:
London
Status:
Project has less than a year to run
Tags:
Prevention
Project Summary

Dr Nicola Guess will investigate the benefits of targeted treatment for different groups of people at high risk of Type 2 diabetes.

She will use the dietary carbohydrate ‘inulin’ to try and improve glucose and insulin levels in people unlikely to benefit from changes to diet and physical activity levels.

Not all fat’s the same: protecting against Type 2 diabetes

Project:
Northern & Yorkshire - Leeds
Status:
Project available for adoption
Tags:
Causes
Project Summary

Dr Roberts is focusing on fat cells, with different types responsible for storing and burning fat. He hopes to find specific signals from ‘good’ beige fat cells, to see if they can improve fat metabolism and protect the body from Type 2 diabetes.

If successful, this research could inform the development of new protective Type 2 diabetes treatments.

Sleep disturbances and Type 2 diabetes

Project:
Northern & Yorkshire - Manchester
Status:
Project available for adoption
Tags:
Causes
Project Summary

Dr Martin Rutter plans to work out if sleep problems can help to predict who’s at risk of Type 2 diabetes. He’ll also look at whether sleep patterns in people with Type 2 diabetes can affect their blood glucose control and risk of complications. This research could help to prevent some people developing Type 2 diabetes and improve the health of people living with the condition.

Are SGLT2 inhibitors safe and effective for people with Type 2?

Project:
Scotland - Edinburgh
Status:
Project available for adoption
Tags:
Healthcare
Project Summary

People with Type 2 diabetes can use drugs called SGLT2 inhibitors to help them manage their blood glucose levels. But unanswered questions remain around how effective and safe they are in real life. Dr Thomas Caparrotta will study large amounts of data from people using these drugs in the real world, to provide important evidence on their effects. This will help doctors and people with Type 2 diabetes to make decisions about the best treatment for them.

Helpful gut bacteria to treat Type 2 diabetes

Project:
England – London
Status:
Project available for adoption
Tags:
Healthcare
Project Summary

The community of bacteria that lives in our gut is different in people with and without Type 2 diabetes. Dr Astrid Hauge-Evans will find out if a diet high in wholegrains could alter this bacteria in people with Type 2 diabetes, and in turn protect insulin-producing cells. This could help us find a new diet-based treatment to improve the health of people living with Type 2 diabetes.

Why does insulin resistance occur in Type 2 diabetes?

Project:
Northern & Yorkshire - Leeds
Status:
Project available for adoption
Tags:
Causes
Project Summary

Insulin resistance is a key feature of Type 2 diabetes. It affects the ability of the body’s cells to take in glucose and causes high blood glucose levels.

Professor Bryant will explore whether proteins involved in this process don’t work properly in people with Type 2 diabetes. This research could improve our understanding of what causes Type 2 diabetes and how to treat it.

Untangling the link between Type 2 diabetes and Alzheimer's disease

Project:
South East - Southampton
Status:
Project available for adoption
Tags:
Complications
Project Summary

People with Type 2 diabetes have an increased risk of developing Alzheimer’s disease, but we don’t know why. Dr Mudher believes that Type 2 diabetes could have a negative effect on a protein in the brain, called ‘Tau’. She wants to find out more about this interaction to see if it can be stopped, to reduce the risk of Alzheimer’s disease in people with Type 2 diabetes.

The cost-effectiveness of DiRECT’s Type 2 remission

Project:
Scotland - Glasgow
Status:
Project not available for adoption
Tags:
Remission
Project Summary

The DiRECT trial is finding out whether a weight management programme, including a low-calorie diet, can put Type 2 diabetes into remission for the long-term. This project will look at the cost effectiveness of this programme when delivered through GP care.

This will give the NHS important information to help work out if this kind of treatment could be offered to people with Type 2 diabetes in the future. 

Keeping mitochondria healthy to prevent Type 2

Project:
Scotland - Dundee
Status:
Project available for adoption
Tags:
Causes
Prevention
Project Summary

High levels of fat can cause mitochondria (important structures inside our cells that burn fuel) to become stressed and break down. This is linked to inflammation and insulin resistance: two important features of Type 2 diabetes.

Professor Hundal wants to know if, and how, unsaturated fats or metformin might protect the mitochondria and keep insulin resistance at bay. In the future, this could help to prevent Type 2 diabetes from developing.

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