Our research projects

We fund world class research

At any one time, we have around 120 research projects making discoveries across the UK. Each of these projects is only possible thanks to the generous support of our members, donors and local groups

Every project is reviewed by experts and approved by our research committee and our panel of people living with diabetes. So you're supporting research of the highest scientific quality, led by researchers with the skills and experience to succeed.

Your support of our research projects means we can keep tackling the complications of diabetes and bring us one step closer to a cure.

Find a research project

Use the search tool to discover research taking place in your local area, or choose a subject or type of diabetes you’re interested in.

Each project page showcases the details of the research, and if you find a research project you could really get behind, you can support it in lots of different ways.

56 results found

Filters
Research Area
Region
Subject

Why does insulin resistance occur in Type 2 diabetes?

Project:
Northern & Yorkshire - Leeds
Status:
Project available for adoption
Tags:
England
Northern & Yorkshire
Type 2
Causes
Project Summary

Insulin resistance is a key feature of Type 2 diabetes. It affects the ability of the body’s cells to take in glucose and causes high blood glucose levels.

Professor Bryant will explore whether proteins involved in this process don’t work properly in people with Type 2 diabetes. This research could improve our understanding of what causes Type 2 diabetes and how to treat it.

Sleep disturbances and Type 2 diabetes

Project:
Northern & Yorkshire - Manchester
Status:
Project not available for adoption
Tags:
Type 2
England - Northern & Yorkshire
Northern & Yorkshire
Causes
Project Summary

Dr Martin Rutter plans to work out if sleep problems can help to predict who’s at risk of Type 2 diabetes. He’ll also look at whether sleep patterns in people with Type 2 diabetes can affect their blood glucose control and risk of complications. This research could help to prevent some people developing Type 2 diabetes and improve the health of people living with the condition.

Are SGLT2 inhibitors safe and effective for people with Type 2?

Project:
Scotland - Edinburgh
Status:
Project available for adoption
Tags:
Healthcare
Type 2
Scotland
Project Summary

People with Type 2 diabetes can use drugs called SGLT2 inhibitors to help them manage their blood glucose levels. But unanswered questions remain around how effective and safe they are in real life. Dr Thomas Caparrotta will study large amounts of data from people using these drugs in the real world, to provide important evidence on their effects. This will help doctors and people with Type 2 diabetes to make decisions about the best treatment for them.

Untangling the link between Type 2 diabetes and Alzheimer's disease

Project:
South East - Southampton
Status:
Project available for adoption
Tags:
England - South East
South East
Complications
Type 2
Project Summary

People with Type 2 diabetes have an increased risk of developing Alzheimer’s disease, but we don’t know why. Dr Mudher believes that Type 2 diabetes could have a negative effect on a protein in the brain, called ‘Tau’. She wants to find out more about this interaction to see if it can be stopped, to reduce the risk of Alzheimer’s disease in people with Type 2 diabetes.

Combining drugs to treat difficult to manage Type 2 diabetes

Project:
Scotland - Aberdeen
Status:
Project available for adoption
Tags:
Type 2
Scotland
Innovation
Healthcare
Rare types of diabetes
Project Summary

Lipodystrophy is a condition that causes fat to be stored differently in the liver, muscle and pancreas. This can lead to a form of Type 2 diabetes that is difficult to manage with diet. Dr Justin Rochford and his team want to investigate if medications that are used to treat the two conditions separately could be combined to manage this difficult form of Type 2 diabetes more easily.

What’s the link between ageing and Type 2 diabetes?

Project:
South East
Status:
Project available for adoption
Tags:
Type 2
England - South East
South East
Causes
Partnership
Project Summary

Changes to our insulin-producing beta cells that happen as we get older are linked to Type 2 diabetes, but we don’t yet know how or why. Professor Masashi Narita will study cells in the lab to shed light on this link. In the future, this could lead to the development of new treatments to combat the effects of ageing on beta cells, and help to prevent Type 2 diabetes.

What aspects of Type 2 diabetes might lead to dementia?

Project:
London
Status:
Project available for adoption
Tags:
Type 2
Complications
London
England
Project Summary

Having type 2 diabetes increases the risk of dementia, but we don’t know why. Dr Eszter Vamos and her team want to find out which diabetes-related factors are involved in the development of dementia, like blood glucose, blood pressure and cholesterol levels. This will help us to find new ways to protect people with type 2 diabetes from dementia.

How is the immune system linked to insulin resistance?

Project:
Scotland - Dundee
Status:
Project available for adoption
Tags:
Scotland
Type 2
Causes
Project Summary

A part of the immune system – called the complement system – is linked to obesity and type 2 diabetes. Professor Hari Hundal wants to understand this link in more detail, by studying the role of a protein that controls this system. He wants to know if stopping the protein from working could help the body to use insulin and burn fat. This could lead to new treatments to prevent type 2 diabetes and treat insulin resistance in people with the condition.

Targeting our body’s recycling system to treat Type 2 diabetes

Project:
Northern and Yorkshire
Status:
Project available for adoption
Tags:
Healthcare
Type 2
Northern & Yorkshire
Project Summary

Type 2 diabetes can get progressively worse over time, as insulin-producing cells in the pancreas stop working properly. Dr Catherine Arden believes something goes wrong with a ‘recycling’ process in our insulin-producing cells, known as autophagy. Her PhD students will carry out experiments to unravel how and why this happens. This could hold the key to finding new treatments to stop Type 2 diabetes from progressing in the future.

Communicating with kidney cells

Project:
East Midlands - Lincoln
Status:
Project not available for adoption
Tags:
Complications
Type 1
Type 2
Type 1 and Type 2
Midlands
Project Summary

Cells in our kidneys usually work together, but having high blood sugar levels for a long time can cause them to misbehave, leading to nephropathy. Professor Paul Squires wants to work out how the conversations between kidney cells change, and whether an existing drug already used to treat retinopathy (eye disease) could be repurposed to help slow or prevent kidney damage in people with diabetes too.

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