Our research projects

We fund world class research

At any one time, we have around 120 research projects making discoveries across the UK. Each of these projects is only possible thanks to the generous support of our members, donors and local groups

Every project is reviewed by experts and approved by our research committee and our panel of people living with diabetes. So you're supporting research of the highest scientific quality, led by researchers with the skills and experience to succeed.

Your support of our research projects means we can keep tackling the complications of diabetes and bring us one step closer to a cure.

Find a research project

Use the search tool to discover research taking place in your local area, or choose a subject or type of diabetes you’re interested in.

Each project page showcases the details of the research, and if you find a research project you could really get behind, you can support it in lots of different ways.

123 results found

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Investigating a potential cause of Type 1 diabetes

Project:
South West - Exeter
Status:
Project not available for adoption
Tags:
Causes
Type 1
England
South West
Project Summary

It’s believed that one of the factors involved in the development of Type 1 diabetes could be a specific type of virus that infects pancreatic beta cells, causing the immune system to attack them. The aim of this project is to investigate key proteins that may be involved in the potential viral infection of beta cells.

The results will improve our understanding of the causes of Type 1 diabetes, ultimately informing future research into the prevention and treatment of the condition. 

Down to details of Type 1 immune attack

Project:
South West - Bristol
Status:
Project available for adoption
Tags:
England
South West
Type 1
Causes
Project Summary

In Type 1 diabetes, the immune system mistakenly attacks several different proteins in the pancreas. One of them is called ZnT8. It seems that people develop Type 1 diabetes at a slower rate if their immune system attacks ZnT8. Dr Gillespie would like to understand the biology behind this attack.

This project will help us understand Type 1 diabetes in more detail and may help researchers develop new therapies to stop the immune attack.

Lymphatics: a new treatment target for kidney disease in people with diabetes?

Project:
London
Status:
Project not available for adoption
Tags:
Complications
London
England
Type 1 and Type 2
Project Summary

Dr David Long and his colleagues are investigating the function of kidney lymphatic vessels in diabetic kidney disease. This will help us to understand whether targeting lymphatic vessels could be a novel treatment strategy for diabetic kidney disease. 

Can self-management therapies help with chronic pain?

Project:
London
Status:
Project not available for adoption
Tags:
Complications
England
London
Type 1 and Type 2
Project Summary

Current treatment options for chronic pain in diabetes (also called painful diabetic neuropathy) are not very effective. A PhD student in Professor McCracken’s lab will investigate whether self-management strategies that focus around psychology could be used to manage pain better.

If successful, it will form a base for developing psychological therapies for people with painful diabetic neuropathy.

Using genetics to predict Type 1 diabetes

Project:
South West - Exeter
Status:
Project available for adoption
Tags:
South West
Type 1
Causes
England
Project Summary

There is a time window of several years between the start of the Type 1 diabetes immune attack and the appearance of symptoms.

Dr Richard Oram has developed a ‘risk calculator’ that uses information from genes linked to Type 1 diabetes to potentially find those at risk of the condition. Now, they want to test the calculator using data from several large studies.

This could help to find people at high risk of Type 1 diabetes in the future, and provide vital knowledge to help create treatments to stop it.

Benefits of exercise for Type 2 diabetes

Project:
Midlands - Nottingham
Status:
Project not available for adoption
Tags:
Innovation
England
Midlands
Type 2
Healthcare
Project Summary

Exercise is known to provide health benefits for people living with Type 2 diabetes and reduce the risk of developing Type 2. But we don’t yet understand why.

Dr Daniel Wilkinson hopes to understand what’s going on inside the body during exercise and why it has positive effects on our health. In the long term, this could help to develop new drugs which also provide these benefits for people with Type 2 diabetes. 

Blocking immune cells that attack the pancreas in Type 1

Project:
Wales - Cardiff
Status:
Project available for adoption
Tags:
Type 1
Causes
Wales
Towards a cure
Project Summary

In Type 1 diabetes, immune cells called ‘B cells’ move into the pancreas and are involved in the destruction of insulin-producing cells. Professor Susan Wong wants to work out why they do this. Her team will study a protein found on B cells and look for differences between people with and without Type 1 diabetes. This could help us develop treatments that stop the immune attack and prevent this condition.

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