Our research projects

We fund world class research

At any one time, we have around 120 research projects making discoveries across the UK. Each of these projects is only possible thanks to the generous support of our members, donors and local groups

Every project is reviewed by experts and approved by our research committee and our panel of people living with diabetes. So you're supporting research of the highest scientific quality, led by researchers with the skills and experience to succeed.

Your support of our research projects means we can keep tackling the complications of diabetes and bring us one step closer to a cure.

Find a research project

Use the search tool to discover research taking place in your local area, or choose a subject or type of diabetes you’re interested in.

Each project page showcases the details of the research, and if you find a research project you could really get behind, you can support it in lots of different ways.

19 results found

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Region
Subject

Exploring blood glucose control in Type 1 diabetes

Project:
Scotland - Edinburgh
Status:
Project is fully funded
Tags:
Healthcare
Type 1
Scotland
Project Summary

Professor Colhoun hopes to understand how blood glucose control in Type 1 diabetes changes over time in different groups of people. These insights could help us find ways to improve blood glucose levels in people with Type 1 diabetes.

Are SGLT2 inhibitors safe and effective for people with Type 2?

Project:
Scotland - Edinburgh
Status:
Project available for adoption
Tags:
Healthcare
Type 2
Scotland
Project Summary

People with Type 2 diabetes can use drugs called SGLT2 inhibitors to help them manage their blood glucose levels. But unanswered questions remain around how effective and safe they are in real life. Dr Thomas Caparrotta will study large amounts of data from people using these drugs in the real world, to provide important evidence on their effects. This will help doctors and people with Type 2 diabetes to make decisions about the best treatment for them.

Testing blood glucose in a flash

Project:
North West - Manchester
Status:
Project available for adoption
Tags:
Healthcare
Type 1
North West
England - North West
England
Project Summary

Flash glucose monitoring gives people with diabetes a simple and painless way to monitor their blood glucose levels. But not everyone who would benefit has access to this life-changing technology. Dr Lalantha Leelarathna will compare the impact and costs of Flash 2 to finger pricks tests in people with Type 1 diabetes. This will provide important evidence that could help make Flash more widely available on the NHS, to transform the lives of people with Type 1 diabetes.

Combining drugs to treat difficult to manage Type 2 diabetes

Project:
Scotland - Aberdeen
Status:
Project available for adoption
Tags:
Type 2
Scotland
Innovation
Healthcare
Rare types of diabetes
Project Summary

Lipodystrophy is a condition that causes fat to be stored differently in the liver, muscle and pancreas. This can lead to a form of Type 2 diabetes that is difficult to manage with diet. Dr Justin Rochford and his team want to investigate if medications that are used to treat the two conditions separately could be combined to manage this difficult form of Type 2 diabetes more easily.

Targeting our body’s recycling system to treat Type 2 diabetes

Project:
Northern and Yorkshire
Status:
Project available for adoption
Tags:
Healthcare
Type 2
Northern & Yorkshire
Project Summary

Type 2 diabetes can get progressively worse over time, as insulin-producing cells in the pancreas stop working properly. Dr Catherine Arden believes something goes wrong with a ‘recycling’ process in our insulin-producing cells, known as autophagy. Her PhD students will carry out experiments to unravel how and why this happens. This could hold the key to finding new treatments to stop Type 2 diabetes from progressing in the future.

Keeping type 2 diabetes in remission: DiRECT extension

Project:
Scotland
Status:
Project not available for adoption
Tags:
Type 2
Scotland
Towards a cure
Healthcare
Project Summary

The DiRECT trial is finding out whether a weight management programme, including a low-calorie diet, can put type 2 diabetes into remission. This project will extend DiRECT for a further five years, to see if this approach can keep type 2 in remission for the long-term. This work could potentially transform the way type 2 diabetes is managed in the future, and could have enormous benefits for people living with the condition.

Fuelling the heart effectively

Project:
London
Status:
Project not available for adoption
Tags:
Type 2
London
Complications
Healthcare
Project Summary

In people with type 2 diabetes, inflammation inside the heart can change the way the heart uses fuel. This increases the risk of heart disease. Dr Dunja Aksentijevic wants to see if a new drug can reduce inflammation in the heart in type 2 diabetes by boosting the activity of the immune system. In the long term, this could lead to a new treatment for people with type 2 diabetes who are showing early signs of heart complications, to slow or stop them from progressing.

Understanding how beta cells release insulin

Project:
South East
Status:
Project available for adoption
Tags:
Type 2
South East
England
Healthcare
Project Summary

Beta cells release insulin into the blood stream, but this complex process isn’t well understood. Dr Benoit Hastoy wants to investigate the process in more detail, to try and improve the effectiveness of existing treatments for people with Type 2 diabetes.

Preventing damage to the retina in diabetes

Project:
Northern Ireland
Status:
Project available for adoption
Tags:
Type 1
Type 2
Complications
Healthcare
Northern Ireland
Project Summary

Having diabetes can lead to damaged blood vessels in the retina, caused by high blood sugar levels. This can lead to visual impairment and blindness. Dr Judith Lechner wants to find out if a protective protein can be used to repair and reduce this damage, and potentially be used as a new treatment option in the future.

How does the heart’s energy change in Type 2 diabetes?

Project:
Northern and Yorkshire
Status:
Project available for adoption
Tags:
Healthcare
Northern & Yorkshire
Type 2
Project Summary

Having Type 2 diabetes changes the way the heart generates the energy it needs to pump blood. Professor Sven Plein wants to know more about these changes, specifically in people who have narrow arteries – a common complication of Type 2 diabetes. Understanding the interaction between Type 2 diabetes and narrow arteries will help with the discovery of new, tailored treatments for people with Type 2 diabetes in the future.

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