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Thiazolidinediones (glitazones)

The only tablet in this group is pioglitazone. This works by reducing insulin resistance and improving insulin sensitivity, allowing the insulin that the body produces to work more effectively. It also helps to protect the cells in the pancreas, allowing them to carry on producing insulin for longer.

They are taken once or twice daily with or without food

Pioglitazone can be used alone or in combination with either a sulphonylurea or metformin or in combination with both. It can also be used in combination with insulin, if intolerant to metformin.

Medications in the Thiazolidinediones / glitazones family

Generic nameTrade name
Pioglitazone + MetforminCompetact

Side effects

All medication has side effects and you should check the patient information leaflet (PIL) supplied with your medication to see which side effects you might experience from your particular medication. Remember that you are unlikely to experience all side effects that are listed, and you may not experience any at all. If you do, speak to your doctor as there may be another diabetes medication you could try instead.

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